Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways.

ABSTRACT:

Introduction

The standard therapy for bronchial asthma consists of combinations of acute (short-acting ß₂-sympathomimetics) and, depending on the severity of disease, additional long-term treatment (including inhaled glucocorticoids, long-acting ß₂-sympathomimetics, anticholinergics, anti-IL-4R antibodies). The antidepressant amitriptyline has been identified as a relevant down-regulator of immunological T_H2-phenotype in asthma, acting-at least partially-through inhibition of acid sphingomyelinase (ASM), an enzyme involved in sphingolipid metabolism. Here, we investigated the non-immunological role of amitriptyline on acute bronchoconstriction, a main feature of airway hyperresponsiveness in asthmatic disease.

Methods

After stimulation of pre

SUBMITTER: Hempel P 

PROVIDER: S-EPMC10617234 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature