Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant bla_OXA-232-Carrying Klebsiella pneumoniae Sequence Type 15 Lineage.

ABSTRACT: Prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) has compromised antimicrobial efficacy against severe infections worldwide. To monitor global spread, we conducted a comprehensive genomic epidemiologic study comparing sequences from 21 bla_OXA-232-carrying CRKP isolates from China with K. pneumoniae sequence type (ST) 15 strains from 68 countries available in GenBank. Phylogenetic and phylogeographic analyses revealed all bla_OXA-232-carrying CRKP isolates belonged to ST15 lineage and exhibited multidrug resistance. Analysis grouped 330 global bla_OXA-232-carrying ST15 CRKP strains into 5 clades, indicating clonal transmission with small genetic distances among multiple strains. The lineage originated in the United States, then spread to Europe,

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10617323 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature