Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana.

ABSTRACT: GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre-extensively drug-resistant variant in Botswana that went undetected by GeneXpert. The public health impact of misdiagnosis emphasizes the need for comprehensive molecular testing to identify resistance and guide treatment.

SUBMITTER: Modongo C 

PROVIDER: S-EPMC10617350 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature