Dataset Information

Changes in Group A Streptococcus emm Types Associated with Invasive Infections in Adults, Spain, 2023.

ABSTRACT: An increase in invasive group A Streptococcus infection was detected in the northeast of Spain in November 2022. A postpandemic decline in the diversity of circulating emm types involved in invasive group A Streptococcus was observed, along with the emergence of emm49 in this geographic area.

SUBMITTER: Belles-Belles A

PROVIDER: S-EPMC10617363 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Changes in Group A Streptococcus emm Types Associated with Invasive Infections in Adults, Spain, 2023.

Bellés-Bellés Alba A Prim Núria N Mormeneo-Bayo Saray S Villalón-Panzano Pilar P Valiente-Novillo Mónica M Jover-Sáenz Alfredo A Aixalà Núria N Bernet Albert A López-González Éric É Prats Ivan I García-González Mercè M

Emerging infectious diseases 20231101 11

An increase in invasive group A Streptococcus infection was detected in the northeast of Spain in November 2022. A postpandemic decline in the diversity of circulating emm types involved in invasive group A Streptococcus was observed, along with the emergence of emm49 in this geographic area. ...[more]

PMID: 37877666

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Project description:BackgroundA few lineages of Group A streptococci (GAS) have been associated with a reemergence of severe invasive streptococcal disease in developed countries. However, the majority of the comparisons between invasive and non-invasive GAS isolates have been performed for collections of reduced genetic diversity or relied on limited typing information to distinguish clones. We characterized by several typing methods and compared a collection of 160 isolates recovered from normally sterile sites with 320 isolates associated with pharyngitis and recovered in the same time period in Portugal.ResultsAlthough most of the isolates belonged to clones that were equally prevalent in invasive infections and pharyngitis, we identified markers of invasiveness, namely the emm types 1 and 64, and the presence of the speA and speJ genes. In contrast, emm4, emm75, and the ssa and speL/M genes were significantly associated with pharyngitis. There was a strong agreement between the emm type, the superantigen (SAg) genes and the clusters defined by pulsed-field gel electrophoresis (PFGE) profiling. Therefore, combinations of particular emm types and SAg genes frequently co-occurred in the same PFGE cluster, but there was no synergistic or antagonistic interaction between them in determining invasiveness. Only macrolide-susceptible PFGE clones were significantly associated with invasive infections or pharyngitis, while the clones of resistant isolates sharing all other molecular properties analyzed were equally prevalent in the two groups of isolates.ConclusionsThis study confirmed the importance of the widely disseminated emm1-T1-ST28 clone in invasive infections but also identified other clones linked to either invasive infections (emm64-ST164) or pharyngitis (emm4-T4-ST39), which may be more limited in their temporal and geographical spread. Clonal properties like some emm types or SAg genes were associated with disease presentation, highlighting the importance of bacterial genetic factors to the outcome of GAS infections, although other, yet unidentified factors may also play an important role.

Dataset Information

Changes in Group A Streptococcus emm Types Associated with Invasive Infections in Adults, Spain, 2023.

Publications

Changes in Group A Streptococcus emm Types Associated with Invasive Infections in Adults, Spain, 2023.

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