Mosaic HIV-1 vaccination induces anti-viral CD8⁺ T cell functionality in the phase 1/2a clinical trial APPROACH.

ABSTRACT:

Importance

The functionality of CD8+ T cells against human immunodeficiency virus-1 (HIV-1) antigens is indicative of HIV-progression in both animal models and people living with HIV. It is, therefore, of interest to assess CD8+ T cell responses in a prophylactic vaccination setting, as this may be an important component of the immune system that inhibits HIV-1 replication. T cell responses induced by the adenovirus serotype 26 (Ad26) mosaic vaccine regimen were assessed previously by IFN-γ ELISpot and flow cytometric assays, yet these assays only measure cytokine production but not the capacity of CD8+ T cells to inhibit replication of HIV-1. In this study, we demonstrate direct anti-viral function of the clinical Ad26 mosaic vaccine regimen through ex vivo inhibition of re

SUBMITTER: van Duijn J 

PROVIDER: S-EPMC10617392 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature