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Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.

ABSTRACT:

Importance

It has been previously shown that genetic variants near CHD1L on chromosome 1 are associated with reduced HIV VL in African populations. However, the impact of these variants on viral diversity and how they restrict viral replication are unknown. We report on a regional association analysis in a South African population and show evidence of selective pressure by variants near CHD1L on HIV RT and gag. Our findings provide further insight into how genetic variability at this locus contributes to host control of HIV in a South African population.

SUBMITTER: Schulz VE

PROVIDER: S-EPMC10617395 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.

Schulz Vanessa E VE Tuff Jeffrey F JF Tough Riley H RH Lewis Lara L Chimukangara Benjamin B Garrett Nigel N Abdool Karim Quarraisha Q Abdool Karim Salim S SS McKinnon Lyle R LR Kharsany Ayesha B M ABM McLaren Paul J PJ

Journal of virology 20230925 10

<h4>Importance</h4>It has been previously shown that genetic variants near <i>CHD1L</i> on chromosome 1 are associated with reduced HIV VL in African populations. However, the impact of these variants on viral diversity and how they restrict viral replication are unknown. We report on a regional association analysis in a South African population and show evidence of selective pressure by variants near <i>CHD1L</i> on HIV RT and gag. Our findings provide further insight into how genetic variabili ...[more]

PMID: 37747237

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