Metal mixtures and DNA methylation measures of biological aging in American Indian populations.

ABSTRACT:

Introduction

Native American communities suffer disproportionately from elevated metal exposures and increased risk for cardiovascular diseases and diabetes. DNA methylation is a sensitive biomarker of aging-related processes and novel epigenetic-based "clocks" can be used to estimate accelerated biological aging that may underlie increased risk. Metals alter DNA methylation, yet little is known about their individual and combined impact on epigenetic age acceleration. Our objective was to investigate the associations of metals on several DNA methylation-based aging measures in the Strong Heart Study (SHS) cohort.

Methods

Blood DNA methylation data from 2,301 SHS participants was used to calculate age acceleration of epigenetic clocks (PhenoAge, GrimAge, DunedinPACE, Hannum,

SUBMITTER: Boyer K 

PROVIDER: S-EPMC10617409 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature