Relative resistance of patient-derived envelope sequences to SERINC5-mediated restriction of HIV-1 infectivity.

ABSTRACT:

Importance

Pathogenesis of HIV-1 is enhanced through several viral-encoded proteins that counteract a range of host restriction molecules. HIV-1 Nef counteracts the cell membrane protein SERINC5 by downregulating it from the cell surface, thereby enhancing virion infectivity. Some subtype B reference Envelope sequences have shown the ability to bypass SERINC5 infectivity restriction independent of Nef. However, it is not clear if and to what extent circulating HIV-1 strains can exhibit resistance to SERINC5 restriction. Using a panel of Envelope sequences isolated from 50 Tanzanians infected with non-B HIV-1 subtypes, we show that the lentiviral reporters pseudotyped with patient-derived Envelopes have reduced sensitivity to SERINC5 and that this sensitivity differed among viral su

SUBMITTER: Nkuwi E 

PROVIDER: S-EPMC10617508 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature