Identification of a novel transcriptional regulator, CorR, for copper stress response in Edwardsiella piscicida.

ABSTRACT: Copper plays a vital role in the host-pathogen interface, potentially making components of the bacterial copper response suitable targets for the development of innovative antimicrobial strategies. The anti-copper arsenal of intracellular pathogens has expanded as an adaptation to survive copper toxicity in order to escape intracellular killing by the host immune system. Herein, we employed transposon insertion sequencing to investigate the genetic mechanisms underlying the survival of Edwardsiella piscicida under copper stress. A novel transcriptional regulator, ETAE_2324 (named CorR), was identified to participate in the response to copper ions by controlling the expression of copA, the core component of cytoplasmic copper homeostasis. Furthermore, CorR regulated the expres

SUBMITTER: Xia F 

PROVIDER: S-EPMC10617541 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature