Retinal microvasculature and incident dementia over 10 years: The Three-City-Alienor cohort.

ABSTRACT:

Introduction

We explored the longitudinal relationship between retinal vascular features and dementia incidence over 10 years.

Methods

Among 584 participants from the Three-City-Alienor (3C-Alienor) population-based cohort, quantitative retinal vascular features (caliber, tortuosity, fractal dimension) were measured using semi-automated software. Dementia was actively diagnosed over the follow-up period.

Results

One hundred twenty-eight participants (21.9%) developed dementia over a median of 7.1 years. In Cox proportional hazards models adjusted for sociodemographic characteristics, apolipoprotein E (APOE) ε4, and vascular factors, increased retinal arteriolar tortuosity was associated with all-cause dementia (hazard ratio per standard deviation increase, 1.21

SUBMITTER: Reboucas SCL 

PROVIDER: S-EPMC10617985 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature