Cell cycle-dependent gene networks for cell proliferation activated by nuclear CK2α complexes.

ABSTRACT: Nuclear expression of protein kinase CK2α is reportedly elevated in human carcinomas, but mechanisms underlying its variable localization in cells are poorly understood. This study demonstrates a functional connection between nuclear CK2 and gene expression in relation to cell proliferation. Growth stimulation of quiescent human normal fibroblasts and phospho-proteomic analysis identified a pool of CK2α that is highly phosphorylated at serine 7. Phosphorylated CK2α translocates into the nucleus, and this phosphorylation appears essential for nuclear localization and catalytic activity. Protein signatures associated with nuclear CK2 complexes reveal enrichment of apparently unique transcription factors and chromatin remodelers during progression through the G₁ phase of the cell c

SUBMITTER: Homma MK 

PROVIDER: S-EPMC10618106 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature