Harmonization of brain PET images in multi-center PET studies using Hoffman phantom scan.

ABSTRACT:

Background

Image harmonization has been proposed to minimize heterogeneity in brain PET scans acquired in multi-center studies. However, standard validated methods and software tools are lacking. Here, we assessed the performance of a framework for the harmonization of brain PET scans in a multi-center European clinical trial.

Method

Hoffman 3D brain phantoms were acquired in 28 PET systems and reconstructed using site-specific settings. Full Width at Half Maximum (FWHM) of the Effective Image Resolution (EIR) and harmonization kernels were estimated for each scan. The target EIR was selected as the coarsest EIR in the imaging network. Using "Hoffman 3D brain Analysis tool," indicators of image quality were calculated before and after the harmonization: The Coefficient of Va

SUBMITTER: Shekari M 

PROVIDER: S-EPMC10618151 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature