MRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice.

ABSTRACT: We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies and T-cell responses in mice. The vaccinated mice were protected against a lethal SFTS virus challenge, suggesting that this mRNA vaccine may be an effective and successful SFTS vaccine candidate.

SUBMITTER: Kim JY 

PROVIDER: S-EPMC10618158 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature