Self-promoted electroactive biomimetic mineralized scaffolds for bacteria-infected bone regeneration.

ABSTRACT: Infected bone defects are a major challenge in orthopedic treatment. Native bone tissue possesses an endogenous electroactive interface that induces stem cell differentiation and inhibits bacterial adhesion and activity. However, traditional bone substitutes have difficulty in reconstructing the electrical environment of bone. In this study, we develop a self-promoted electroactive mineralized scaffold (sp-EMS) that generates weak currents via spontaneous electrochemical reactions to activate voltage-gated Ca²⁺ channels, enhance adenosine triphosphate-induced actin remodeling, and ultimately achieve osteogenic differentiation of mesenchymal stem cells by activating the BMP2/Smad5 pathway. Furthermore, we show that the electroactive interface provided by the sp-EMS inhibits bacte

SUBMITTER: Li Z 

PROVIDER: S-EPMC10618168 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature