Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function.

ABSTRACT: Clinically, cardiac dysfunction is a key component of sepsis-induced multi-organ failure. Mitochondria are essential for cardiomyocyte homeostasis, as disruption of mitochondrial dynamics enhances mitophagy and apoptosis. However, therapies targeted to improve mitochondrial function in septic patients have not been explored. Transcriptomic data analysis revealed that the peroxisome proliferator-activated receptor (PPAR) signaling pathway in the heart was the most significantly decreased in the cecal ligation puncture-treated mouse heart model, and PPARα was the most notably decreased among the three PPAR family members. Male Ppara^fl/fl (wild-type), cardiomyocyte-specific Ppara-deficient (Ppara^ΔCM), and myeloid-specific Ppara-deficient (Ppara^ΔMac) mice were

SUBMITTER: Zhu XX 

PROVIDER: S-EPMC10618178 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature