A subthalamo-parabrachial glutamatergic pathway is involved in stress-induced self-grooming in mice.

ABSTRACT: Excessive self-grooming is an important behavioral phenotype of the stress response in rodents. Elucidating the neural circuit that regulates stress-induced self-grooming may suggest potential treatment to prevent maladaptation to stress that is implicated in emotional disorders. Stimulation of the subthalamic nucleus (STN) has been found to induce strong self-grooming. In this study we investigated the role of the STN and a related neural circuit in mouse stress-related self-grooming. Body-restraint and foot-shock stress-induced self-grooming models were established in mice. We showed that both body restraint and foot shock markedly increased the expression of c-Fos in neurons in the STN and lateral parabrachial nucleus (LPB). Consistent with this, the activity of STN neurons and LPB glut

SUBMITTER: Jia T 

PROVIDER: S-EPMC10618182 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature