Composition of gut microbiota involved in alleviation of dexamethasone-induced muscle atrophy by whey protein.

ABSTRACT: Skeletal muscle atrophy is a condition associated with increased morbidity and mortality. While the concept of the gut-muscle axis has been proposed, the role of gut microbiota in dexamethasone (DEX)-induced skeletal muscle atrophy remains largely unknown, limiting its clinical applications. In this study, we found that administration of DEX caused a shift in the gut microbiota of mice, characterized by an increased ratio of Firmicutes/Bacteroidota and a reduction in alpha diversity. We also identified 480 new operational taxonomic units (OTUs), while 1168 specific OTUs were lost. Our Spearman correlation analysis revealed 28 key taxonomic genera of bacteria that were positively or negatively associated with skeletal muscle strength and weight (r: -0.881 to 0.845, p < 0.05). Moreover, supp

SUBMITTER: Qiu J 

PROVIDER: S-EPMC10618183 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature