A two-arm analysis of the immune response to heterologous boosting of inactivated SARS-CoV-2 vaccines.

ABSTRACT: Several vaccine programs were introduced during the COVID-19 pandemic, which included inactivated virus, DNA viral vectors and mRNA vaccines. Booster programs are recommended, especially for those in high-risk groups. However, many of these booster programs involve heterologous vaccines. This study enrolled volunteers who first received two full-dose CoronaVac vaccinations before receiving heterologous boosters with DNA- and/or mRNA-vaccines for an additional 2 doses (n = 40) or an additional 3 doses (n = 16). Our results showed no difference in side effects, neutralizing antibodies, or T-cell responses for any of the heterologous vaccination programs. However, the neutralizing capacity and IFN-γ responses against the Omicron variant in volunteers who received 4 or 5 doses were improved. P

SUBMITTER: Nithichanon A 

PROVIDER: S-EPMC10618206 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature