Structure and dynamics of pteridine reductase 1: the key phenomena relevant to enzyme function and drug design.

ABSTRACT: Pteridine reductase 1 (PTR1) is a folate and pterin pathway enzyme unique for pathogenic trypanosomatids. As a validated drug target, PTR1 has been the focus of recent research efforts aimed at finding more effective treatments against human parasitic diseases such as leishmaniasis or sleeping sickness. Previous PTR1-centered structural studies highlighted the enzyme characteristics, such as flexible regions around the active site, highly conserved structural waters, and species-specific differences in pocket properties and dynamics, which likely impacts the binding of natural substrates and inhibitors. Furthermore, several aspects of the PTR1 function, such as the substrate inhibition phenomenon and the level of ligand binding cooperativity in the enzyme homotetramer, likely related to th

SUBMITTER: Panecka-Hofman J 

PROVIDER: S-EPMC10618315 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature