Isopropyl alcohol inhalation versus 5-HT₃ antagonists for treatment of nausea: a meta-analysis of randomised controlled trials.

ABSTRACT:

Purpose

Nausea is a common and unpleasant sensation for which current therapies such as serotonin (5-HT₃) antagonists are often ineffective, while also conferring a risk of potential adverse events. Isopropyl alcohol (IPA) has been proposed as a treatment for nausea. We aimed to compare IPA with 5-HT₃ antagonists for the treatment of nausea across all clinical settings.

Methods

MEDLINE, EMBASE, PubMed, CENTRAL and CINAHL were searched from inception to 17 July 2023 for randomised controlled trials (RCTs) comparing inhaled IPA and a 5-HT₃ antagonist for treatment of nausea. Severity and duration of nausea, rescue antiemetic use, adverse events and patient satisfaction were the outcomes sought. Risk of bias (RoB) was assessed using Cochrane RoB

SUBMITTER: Kimber JS 

PROVIDER: S-EPMC10618376 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature