Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells.

ABSTRACT: Pregnancy imposes a substantial metabolic burden on women, but little is known about whether or how multiple pregnancies increase the risk of maternal postpartum diabetes. In this study, we assessed the metabolic impact of multiple pregnancies in humans and in a rodent model. Mice that underwent multiple pregnancies had increased adiposity, but their glucose tolerance was initially improved compared to those of age-matched virgin mice. Later, however, insulin resistance developed over time, but insulin secretory function and compensatory pancreatic β cell proliferation were impaired in multiparous mice. The β cells of multiparous mice exhibited aging features, including telomere shortening and increased expression of Cdkn2a. Single-cell RNA-seq analysis revealed that the β cells of multipa

SUBMITTER: Moon JH 

PROVIDER: S-EPMC10618440 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature