Development of a multivalent adjuvanted inactivated vaccine against variant arthrotropic avian reoviruses.

ABSTRACT: Variant avian reoviruses (ARVs) are economically important emerging pathogens of poultry, which mainly affect young broiler chickens and cause significant production losses. Currently, there are no effective commercial vaccines available for control and prevention of emerging variant ARVs. In this study, monovalent inactivated adjuvated (20% Emulsigen D) broiler breeder vaccines containing antigens from ARV genotype cluster (C) group -2, -4, -5, or -6, and a multivalent vaccine containing antigens from all the four indicated genotypic cluster groups were developed and evaluated for their efficacy in protecting broiler progenies against homologous or heterologous ARV challenge. The use of monovalent or multivalent inactivated vaccines in a prime-boost immunization strategy induced the produ

SUBMITTER: Ayalew LE 

PROVIDER: S-EPMC10618555 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature