Bayesian nonparametric method for genetic dissection of brain activation region.

ABSTRACT: Biological evidence indicewates that the brain atrophy can be involved at the onset of neuropathological pathways of Alzheimer's disease. However, there is lack of formal statistical methods to perform genetic dissection of brain activation phenotypes such as shape and intensity. To this end, we propose a Bayesian hierarchical model which consists of two levels of hierarchy. At level 1, we develop a Bayesian nonparametric level set (BNLS) model for studying the brain activation region shape. At level 2, we construct a regression model to select genetic variants that are strongly associated with the brain activation intensity, where a spike-and-slab prior and a Gaussian prior are chosen for feature selection. We develop efficient posterior computation algorithms based on the Markov chain Mo

SUBMITTER: Jin Z 

PROVIDER: S-EPMC10618557 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature