Depression and risk of sarcopenia: a national cohort and Mendelian randomization study.

ABSTRACT:

Background

Depression and the increased risk of sarcopenia are prevalent among the elderly population. However, the causal associations between these factors remain unclear. To investigate the potential association between depression and the risk of sarcopenia in older adults, this study was performed.

Methods

In the baseline survey, a total of 14,258 individuals aged 40 and above from the China Health and Retirement Longitudinal Study (2015) participated. We initially described the baseline prevalence of the disease. Then, logistic regression and restricted cubic spline (RCS) regression were conducted to assess the relationship between depression and sarcopenia. Subgroup analysis was performed to validate the robustness of the findings. Additionally, we conducted Mendelian

SUBMITTER: Zhong Q 

PROVIDER: S-EPMC10618558 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature