Systematic analysis of cuproptosis-related genes in immunological characterization and predictive drugs in Alzheimer's disease.

ABSTRACT:

Objectives

This study aimed to make a systematic analysis of cuproptosis-related genes (CRGs) in immunological characterization and predictive drugs in Alzheimer's disease (AD) through bioinformatics and biological experiments.

Methods

The molecular clusters related to CRGs and associated immune cell infiltrations in AD were investigated. The diagnostic models were constructed for AD and different AD subtypes. Moreover, drug prediction and molecular docking were also performed. Subsequently, a molecular dynamics (MD) simulation was conducted to further verify the findings. Finally, RT-qPCR validation was performed.

Results

The characterization of 12 AD-related CRGs was evaluated in AD, and a diagnostic model for AD showed a satisfying discrimination power based on fiv

SUBMITTER: Nie B 

PROVIDER: S-EPMC10618683 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature