Leveraging ToxCast data and protein sequence conservation to complement aquatic life criteria derivation.

ABSTRACT: The USEPA's 1985 guidelines for the derivation of aquatic life criteria (ALC) are robust but data-intensive. For many chemicals, the extensive in vivo data sets required for ALC derivation are not available. Thus, alternative analyses and processes that can provide provisional values to guide states, tribes, and other stakeholders while data accumulate and more rigorous criteria are derived would be beneficial. The overarching purpose of this study was to assess the feasibility of using data from new approach methodologies (NAMs) like ToxCast to derive first-pass, provisional values to guide chemical prioritization and resource management as a complement to traditional ALC derivation. To address this goal, the study objectives were to (1) estimate chemical potency using data from NAMs for

SUBMITTER: Schaupp CM 

PROVIDER: S-EPMC10618725 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature