Targeted Investigational Oncology Agents in the NCI-60: A Phenotypic Systems-based Resource.

ABSTRACT: The NCI-60 human tumor cell line panel has proved to be a useful tool for the global cancer research community in the search for novel chemotherapeutics. The publicly available cell line characterization and compound screening data from the NCI-60 assay have significantly contributed to the understanding of cellular mechanisms targeted by new oncology agents. Signature sensitivity/resistance patterns generated for a given chemotherapeutic agent against the NCI-60 panel have long served as fingerprint presentations that encompass target information and the mechanism of action associated with the tested agent. We report the establishment of a new public NCI-60 resource based on the cell line screening of a large and growing set of 175 FDA-approved oncology drugs (AOD) plus >825 clinical and

SUBMITTER: Morris J 

PROVIDER: S-EPMC10618733 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature