Kidney Function and Risk of Renal Cell Carcinoma.

ABSTRACT:

Background

We evaluated the temporal association between kidney function, assessed by estimated glomerular filtration rate (eGFR), and the risk of incident renal cell carcinoma (RCC). We also evaluated whether eGFR could improve RCC risk discrimination beyond established risk factors.

Methods

We analyzed the UK Biobank cohort, including 463,178 participants of whom 1,447 were diagnosed with RCC during 5,696,963 person-years of follow-up. We evaluated the temporal association between eGFR and RCC risk using flexible parametric survival models, adjusted for C-reactive protein and RCC risk factors. eGFR was calculated from creatinine and cystatin C levels.

Results

Lower eGFR, an indication of poor kidney function, was associated with higher RCC risk when measured up to 5

SUBMITTER: Alcala K 

PROVIDER: S-EPMC10618735 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature