A case-control study and systematic review of the association between glutathione S-transferase genes and chronic kidney disease.

ABSTRACT:

Background

GSTM1 deletion was reported to be associated with CKD progression in cohort studies. However, the results of case‒control studies were conflicting. The association between GST genes and CKD progression needs to be studied in China. Therefore, we conducted this case‒control study and systematic review for Southwest China to outline the association between GST genes and CKD.

Methods

CKD patients and healthy controls were enrolled from June 1, 2022 to 1 August 2022. Reported case‒control studies were identified by searching databases until 1 September 2022 for meta-analysis.

Results

Significant associations were found between deletions of GSTM1 and GSTT1 and CKD risk (all P < 0.01) but not in GSTP1 rs1695 (all P > 0.05) in Southwest China. Then,

SUBMITTER: Peng J 

PROVIDER: S-EPMC10618768 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature