Inflammatory related plasma proteins involved in acute preschool wheeze.

ABSTRACT:

Background

Preschool wheeze is a risk factor for asthma development. However, the molecular mechanism behind a wheezing episode is not well understood.

Objective

Our aims were to assess the association of plasma proteins with acute preschool wheeze and to study the proteins with differential expression at the acute phase at revisit after 3 months. Additionally, to investigate the relationship between protein expression and clinical parameters.

Method

We measured 92 inflammatory proteins in plasma and clinical parameters from 145 children during an episode of preschool wheeze (PW) and at the revisit after 3 months (PW-R, n = 113/145) and 101 healthy controls (HC) aged 6-48 months in the GEWAC cohort using the antibody-mediated proximity extension-based assay (Olink Pro

SUBMITTER: Holmdahl I 

PROVIDER: S-EPMC10618892 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature