Cytosolic DNA accumulation promotes breast cancer immunogenicity via a STING-independent pathway.

ABSTRACT:

Background

Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, ICB alone has demonstrated only benefit in a small subset of patients with breast cancer. Recent studies have shown that agents targeting DNA damage response improve the efficacy of ICB and promote cytosolic DNA accumulation. However, recent clinical trials have shown that these agents are associated with hematological toxicities. More effective therapeutic strategies are urgently needed.

Methods

Primary triple negative breast cancer tumors were stained for cytosolic single-stranded DNA (ssDNA) using multiplex immunohistochemical staining. To increase cytosolic ssDNA, we genetically silenced TREX1. The role of tumor cytosolic ssDNA in promoting tumor immunogenicity and antitumor immune

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10619126 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature