Protein conformational ensembles in function: roles and mechanisms.

ABSTRACT: The sequence-structure-function paradigm has dominated twentieth century molecular biology. The paradigm tacitly stipulated that for each sequence there exists a single, well-organized protein structure. Yet, to sustain cell life, function requires (i) that there be more than a single structure, (ii) that there be switching between the structures, and (iii) that the structures be incompletely organized. These fundamental tenets called for an updated sequence-conformational ensemble-function paradigm. The powerful energy landscape idea, which is the foundation of modernized molecular biology, imported the conformational ensemble framework from physics and chemistry. This framework embraces the recognition that proteins are dynamic and are always interconverting between conform

SUBMITTER: Nussinov R 

PROVIDER: S-EPMC10619138 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature