Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1.

ABSTRACT: Protein lipidation is a post-translational modification that confers hydrophobicity on protein substrates to control their cellular localization, mediate protein trafficking, and regulate protein function. In particular, protein prenylation is a C-terminal modification on proteins bearing canonical motifs catalyzed by prenyltransferases. Prenylated proteins have been of interest due to their numerous associations with various diseases. Chemical proteomic approaches have been pursued over the last decade to define prenylated proteomes (prenylome) and probe their responses to perturbations in various cellular systems. Here, we describe the discovery of prenylation of a non-canonical prenylated protein, ALDH9A1, which lacks any apparent prenylation motif. This enzyme was initially identified

SUBMITTER: Suazo KF 

PROVIDER: S-EPMC10619140 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature