Trends in teicoplanin loading dose implementation from 2010 to 2019 and evaluation of safety and efficacy factors: a retrospective cohort study based on a Japanese administrative claims database.

ABSTRACT:

Background

The loading dose of teicoplanin (TEIC) is recommended for implementation. However, there is significant discrepancy between the dose settings in the package insert and, in the guidelines, and the actual status of loading doses in Japan is unclear. Furthermore, TEIC causes liver injury as side effect. Although the risk of developing liver injury has not been reported to be increased following a loading dose based on the guidelines, there is a lack of reports in large populations. Therefore, we evaluated the trend in the loading dose and factors affecting the efficacy and safety of TEIC administration.

Methods

A Japanese administrative claims database was used in this study. Trends in loading doses were evaluated in target populations administered TEIC between 2010

SUBMITTER: Goto R 

PROVIDER: S-EPMC10619217 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature