Effects of chromosomal translocation characteristics on fertilization and blastocyst development - a retrospective cohort study.

ABSTRACT:

Objective

To determine the effect of different translocation characteristics on fertilization rate and blastocyst development in chromosomal translocation patients.

Methods

This retrospective cohort study was conducted at the Third Affiliated Hospital of Zhengzhou University From January 2017 to December 2022.All couples were diagnosed as reciprocal translocation or Robertsonian translocation by karyotype of peripheral blood lymphocytes test. After adjusting for confounding factors, the effect of chromosomal rearrangement characteristics, such as carrier sex, translocation type, chromosome length and break sites, on fertilization rate and embryo development were analysed separately using multiple linear regression.

Results

In cases of Robertsonian translocation (RobT)

SUBMITTER: Wu S 

PROVIDER: S-EPMC10619257 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature