Estrogen-related genes for thyroid cancer prognosis, immune infiltration, staging, and drug sensitivity.

ABSTRACT:

Background

Thyroid cancer (THCA) has become increasingly common in recent decades, and women are three to four times more likely to develop it than men. Evidence shows that estrogen has a significant impact on THCA proliferation and growth. Nevertheless, the effects of estrogen-related genes (ERGs) on THCA stages, immunological infiltration, and treatment susceptibility have not been well explored.

Methods

Clinicopathological and transcriptome data of patients with THCA from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were cleaned before consensus clustering. Differential expression analysis was performed on the genes expressed between THCA and paraneoplastic tissues in TCGA, and Wayne analysis was performed on the ERGs obtained from the Gene Set Enr

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10619281 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature