Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis.

ABSTRACT:

Background

Sepsis is one of the leading causes of death. Treatment attempts targeting the immune response regularly fail in clinical trials. As HCMV latency can modulate the immune response and changes the immune cell composition, we hypothesized that HCMV serostatus affects mortality in sepsis patients.

Methods

We determined the HCMV serostatus (i.e., latency) of 410 prospectively enrolled patients of the multicenter SepsisDataNet.NRW study. Patients were recruited according to the SEPSIS-3 criteria and clinical data were recorded in an observational approach. We quantified 13 cytokines at Days 1, 4, and 8 after enrollment. Proteomics data were analyzed from the plasma samples of 171 patients.

Results

The 30-day mortality was higher in HCMV-seropositive patients than

SUBMITTER: Unterberg M 

PROVIDER: S-EPMC10619294 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature