Increased resting-state thalamocortical functional connectivity in children and young adults with autism spectrum disorder.

ABSTRACT: There is converging evidence that abnormal thalamocortical interactions contribute to attention deficits and sensory sensitivities in autism spectrum disorder (ASD). However, previous functional MRI studies of thalamocortical connectivity in ASD have produced inconsistent findings in terms of both the direction (hyper vs. hypoconnectivity) and location of group differences. This may reflect, in part, the confounding effects of head motion during scans. In the present study, we investigated resting-state thalamocortical functional connectivity in 8-25 year-olds with ASD and their typically developing (TD) peers. We used pre-scan training, on-line motion correction, and rigorous data quality assurance protocols to minimize motion confounds. ASD participants showed increased thalamic connecti

SUBMITTER: Baran B 

PROVIDER: S-EPMC10619334 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature