Developmental changes in endogenous testosterone have sexually-dimorphic effects on spontaneous cortical dynamics.

ABSTRACT: The transition from childhood to adolescence is associated with an influx of sex hormones, which not only facilitates physical and behavioral changes, but also dramatic changes in neural circuitry. While previous work has shown that pubertal hormones modulate structural and functional brain development, few of these studies have focused on the impact that such hormones have on spontaneous cortical activity, and whether these effects are modulated by sex during this critical developmental window. Herein, we examined the effect of endogenous testosterone on spontaneous cortical activity in 71 typically-developing youth (ages 10-17 years; 32 male). Participants completed a resting-state magnetoencephalographic (MEG) recording, structural MRI, and provided a saliva sample for hormone analysis.

SUBMITTER: Picci G 

PROVIDER: S-EPMC10619376 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature