Spatiotemporal dedifferentiation of the global brain signal topography along the adult lifespan.

ABSTRACT: Age-related variations in many regions and/or networks of the human brain have been uncovered using resting-state functional magnetic resonance imaging. However, these findings did not account for the dynamical effect the brain's global activity (global signal [GS]) causes on local characteristics, which is measured by GS topography. To address this gap, we tested GS topography including its correlation with age using a large-scale cross-sectional adult lifespan dataset (n = 492). Both GS topography and its variation with age showed frequency-specific patterns, reflecting the spatiotemporal characteristics of the dynamic change of GS topography with age. A general trend toward dedifferentiation of GS topography with age was observed in both spatial (i.e., less differences of GS between dif

SUBMITTER: Ao Y 

PROVIDER: S-EPMC10619384 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature