The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory synaptic transmission and potentially cognitive impairment. Current methods for measuring the excitation/inhibition (E/I) ratio are mostly invasive, but recent research combining neurocomputational modeling with measurements of local field potentials has indicated that the slope with which the power spectrum of neuronal activity captured by electro- and/or magnetoencephalography rolls off, is a non-invasive biomarker of the E/I ratio. A steeper roll-off is associated with a stronger inhibition. This novel method can be applied to assess the E/I ratio in people with multiple sclerosis (pwMS), detect the effect of medication such as benzod

SUBMITTER: Akbarian F 

PROVIDER: S-EPMC10619404 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature