Micro-structured polymer fixed targets for serial crystallography at synchrotrons and XFELs.

ABSTRACT: Fixed targets are a popular form of sample-delivery system used in serial crystallography at synchrotron and X-ray free-electron laser sources. They offer a wide range of sample-preparation options and are generally easy to use. The supports are typically made from silicon, quartz or polymer. Of these, currently, only silicon offers the ability to perform an aperture-aligned data collection where crystals are loaded into cavities in precise locations and sequentially rastered through, in step with the X-ray pulses. The polymer-based fixed targets have lacked the precision fabrication to enable this data-collection strategy and have been limited to directed-raster scans with crystals randomly distributed across the polymer surface. Here, the fabrication and first results from a new polymer-

SUBMITTER: Carrillo M 

PROVIDER: S-EPMC10619457 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature