A conserved HOTAIRM1-HOXA1 regulatory axis contributes early to neuronal differentiation.

ABSTRACT: HOTAIRM1 is unlike most long non-coding RNAs in that its sequence is highly conserved across mammals. Such evolutionary conservation points to it having a role in key cellular processes. We previously reported that HOTAIRM1 is required to curb premature activation of downstream HOXA genes in a cell model recapitulating their sequential induction during development. We found that it regulates 3' HOXA gene expression by a mechanism involving epigenetic and three-dimensional chromatin changes. Here we show that HOTAIRM1 participates in proper progression through the early stages of neuronal differentiation. We found that it can associate with the HOXA1 transcription factor and contributes to its downstream transcriptional program. Particularly, HOTAIRM1 affects the NANOG/

SUBMITTER: Segal D 

PROVIDER: S-EPMC10619521 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature