Birth spacing and risk of adverse pregnancy and birth outcomes: A systematic review and dose-response meta-analysis.

ABSTRACT:

Introduction

The association between extreme birth spacing and adverse outcomes is controversial, and available evidence is fragmented into different classifications of birth spacing.

Material and methods

We conducted a systematic review of observational studies to evaluate the association between birth spacing (i.e., interpregnancy interval and interoutcome interval) and adverse outcomes (i.e., pregnancy complications, adverse birth outcomes). Pooled odds ratios (ORs) with 95% confidence intervals (CI) were calculated using a random-effects model, and the dose-response relationships were evaluated using generalized least squares trend estimation.

Results

A total of 129 studies involving 46 874 843 pregnancies were included. In the general population, compared with an

SUBMITTER: Ni W 

PROVIDER: S-EPMC10619614 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature