Expanding flavone and flavonol production capabilities in <i>Escherichia coli</i>.

ABSTRACT: Flavones and flavonols are important classes of flavonoids with nutraceutical and pharmacological value, and their production by fermentation with recombinant microorganisms promises to be a scalable and economically favorable alternative to extraction from plant sources. Flavones and flavonols have been produced recombinantly in a number of microorganisms, with Saccharomyces cerevisiae typically being a preferred production host for these compounds due to higher yields and titers of precursor compounds, as well as generally improved ability to functionally express cytochrome P450 enzymes without requiring modification to improve their solubility. Recently, a rapid prototyping platform has been developed for high-value compounds in E. coli, and a number of gatekeeper (2S</

SUBMITTER: Yiakoumetti A 

PROVIDER: S-EPMC10619664 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature