Causal relationship between spondylarthritis and stroke in a European population: a two sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies have found an increased risk of stroke in patients with spondyloarthritis, but the results are susceptible to reverse causality and confounders. Therefore, the study aimed to further explore the association between spondyloarthritis and different subtypes of stroke by using a two sample Mendelian randomization (MR) analysis.

Methods

Genetic instrumental variables for spondyloarthritis were identified using summary level data from a genome-wide association study involving 201,581 people. Summary statistics from the Multiancestry Genome-wide Association Study of Stroke Consortium were used to obtain genetic data on stroke. There was no sample overlap between the exposure and outcome datasets. Inverse-variance weighted was considered the primary

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10619678 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature