Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study.

ABSTRACT:

Background

Radiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS.

Objective

To examine functional connectivity differences between RIS and healthy controls using resting-state functional magnetic resonance imaging (fMRI).

Methods

Resting-state fMRI data in 25 RIS patients and 28 healthy controls were analyzed using an independent component analysis; in addition, seed-based correlation analysis was used to obtain more information about specific differences in the functional connectivity of resting-state networks. Participants also underwent neuropsychological testing.

Result

SUBMITTER: Benito-Leon J 

PROVIDER: S-EPMC10619710 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature