Unraveling the relationships between alpha- and beta-adrenergic modulation and the risk of heart failure.

ABSTRACT:

Background

The effects of α and ß adrenergic receptor modulation on the risk of developing heart failure (HF) remains uncertain due to a lack of randomized controlled trials. This study aimed to estimate the effects of α and ß adrenergic receptors modulation on the risk of HF and to provide proof of principle for genetic target validation studies in HF.

Methods

Genetic variants within the cis regions encoding the adrenergic receptors α1A, α2B, ß1, and ß2 associated with blood pressure in a 757,601-participant genome-wide association study (GWAS) were selected as instruments to perform a drug target Mendelian randomization study. Effects of these variants on HF risk were derived from the HERMES GWAS (542,362 controls; 40,805 HF cases).

Results

Lower α1A or ß1 activity

SUBMITTER: Baudier C 

PROVIDER: S-EPMC10619754 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature