Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics.

ABSTRACT:

Aims

Long term survivors of haematopoietic stem cell transplantation (HSCT) for β-thalassemia major are designated "ex-thalassaemics". Whether ex-thalassaemics continue to harbour residual myocardial dysfunction and thereby stand the risk of heart failure-related morbidity and mortality is unknown. The aim of this study was to assess the prevalence and predictors of subclinical left ventricular (LV) dysfunction in an apparently normal ex-thalassaemic population.

Methods

We conducted a single centre cross-sectional study among 62 ex-thalassaemic patients, who had undergone HSCT for β-thalassaemia major at our centre. The primary outcome variable was LV systolic dysfunction, as assessed by 1) LV global longitudinal strain (GLS) derived by 2D speckle tracking echocardiography a

SUBMITTER: Paul A 

PROVIDER: S-EPMC10619803 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature