Genomic and demographic processes differentially influence genetic variation across the human X chromosome.

ABSTRACT: Many forces influence genetic variation across the genome including mutation, recombination, selection, and demography. Increased mutation and recombination both lead to increases in genetic diversity in a region-specific manner, while complex demographic patterns shape patterns of diversity on a more global scale. While these processes act across the entire genome, the X chromosome is particularly interesting because it contains several distinct regions that are subject to different combinations and strengths of these forces: the pseudoautosomal regions (PARs) and the X-transposed region (XTR). The X chromosome thus can serve as a unique model for studying how genetic and demographic forces act in different contexts to shape patterns of observed variation. We therefore sought to explore d

SUBMITTER: Cotter DJ 

PROVIDER: S-EPMC10619814 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature